Cellular absorption data, epigenetic gene expression results, full ingredients, and an honest assessment from a THREE Founding Member who has taken this daily for 3 years.
THREE Vitalité is a superfood blend and multivitamin complex manufactured by THREE International (iii International LLC, Lehi, Utah). It uses the company's proprietary Cellular Absorption Technology (CAT) — specifically an enzyme blend that breaks down naturally-derived vitamins, minerals, and amino acids into their bioactive forms before they reach the intestinal wall.
The product comes as a 30-day supply: 4 capsules containing the superfood, vitamin, mineral, enzyme, probiotic, and berry blend, plus 1 Omega-3 complex softgel. It contains no artificial ingredients, colors, flavors, additives, gluten, casein, dairy, soy, corn, nuts, sugar, artificial preservatives, or fillers.
I have taken Vitalité daily for 3 years. I became a THREE Founding Member after 2 months of independently reviewing the clinical research before I agreed to represent any THREE product. Vitalité is the first product I recommend to anyone beginning a THREE protocol — and the clinical data is why.
Every ingredient is naturally-derived. THREE states that naturally-derived vitamins and minerals have superior absorption compared to synthetic counterparts. The enzyme blend is what activates the bioavailability advantage.
| Ingredient | What It Does |
|---|---|
| Superfood Blend | Chlorophyll-rich ingredients that bind to toxins and support elimination. Provides foundational phytonutrient density. |
| Naturally-Derived Vitamins & Minerals | Full vitamin and mineral complex from natural sources. Superior absorption vs synthetic pharmaceutical-grade compounds. |
| 72 Trace Minerals + Amino Acids | Trace minerals activate enzymes throughout the body. Amino acids are the building blocks of protein synthesis. |
| Enzyme Blend | The core of THREE's CAT technology for Vitalité. Breaks down all nutrients into bioactive form before the intestinal wall — the mechanism behind the 44% absorption result. |
| Probiotics (100M CFU, 3 strains) | Supports gut microbiome health. THREE notes that 80% of the immune system is gut-resident — probiotic support directly impacts immune function. |
| Berry Blend (10 berries) | Phytonutrients that support healthy gene expression. The polyphenol content of this blend is what drove the 840% BDNF upregulation in the epigenetic study. |
| Omega-3 Complex Softgel | Wild-caught fish oil with the same Omega-3 profile as a fresh salmon fillet. Supports heart, brain, joint, and eye function. |
| Component | Form | Key Contents |
|---|---|---|
| Capsule 1–2 | Vegetable capsule | Superfood blend, naturally-derived vitamins, chelated minerals, 72 trace minerals + amino acids |
| Capsule 3 | Vegetable capsule | Enzyme blend (bioavailability activator), probiotics — 100M CFU, 3 strains (L. acidophilus, B. longum, L. plantarum) |
| Capsule 4 | Vegetable capsule | 10-Berry polyphenol blend (açai, blueberry, pomegranate, goji, raspberry, elderberry, cranberry, strawberry, tart cherry, grape seed) |
| Softgel | Omega-3 complex | Wild-caught fish oil profile equivalent to fresh salmon — EPA + DHA for heart, brain, joint, and eye function |
Standard synthetic multivitamins — the kind available in pharmacies and big-box stores — are manufactured with chemical binders and industrial fillers. The body can treat these as non-organic compounds. Cellular absorption rates for standard supplements can be as low as 10%.
This is not a marketing claim. It is the baseline established by the same Caco-2 assay methodology that pharmaceutical companies use to test drug bioavailability. The control in THREE's own study — a standard organic molecule with no delivery technology — absorbed at exactly 10%.
Vitalité's enzyme blend addresses this by converting every nutrient into its bioactive form before it encounters the intestinal wall, rather than leaving that conversion to the body's digestive process. The result: 44% cellular absorption vs. 10% for the control.
"The $12 multivitamin isn't failing you. Your body can't absorb it. That's a delivery problem — and THREE's enzyme technology is the solution that the absorption data supports." — Ed Drost
BDNF — Brain-Derived Neurotrophic Factor — is the gene most directly governing neuroplasticity, memory formation, and cognitive resilience. In THREE's 2023 epigenetic study, Vitalité's 10-berry polyphenol blend upregulated BDNF by 840% in THLE-2 human liver cells — the highest single gene expression result across all products tested.
This result is consistent with published polyphenol research. Berry-derived polyphenols have demonstrated BDNF-modulatory effects in peer-reviewed literature: Spencer et al. (2012, Genes & Nutrition) established that dietary flavonoids interact with the BDNF signaling cascade; Rendeiro et al. (2015, British Journal of Nutrition) showed blueberry polyphenol supplementation improved spatial memory associated with BDNF pathway activation. THREE's 10-berry blend targets this same mechanism through its polyphenol density.
Additionally, Vitalité showed: GLP-1 gene upregulation +348% (metabolic health), nrf1 +224% (cellular energy), ppara +216% (ATP production), nfkb −172% (inflammatory suppression). These are in-vitro results and do not guarantee identical outcomes in human subjects.
In THREE International's 2023 epigenetic gene expression study, conducted by Paul Davis, Ph.D. and Catherine Davis, Ph.D. (Trinity Bioactives Ltd) with Dr. Dan Gubler using THLE-2 human liver cells and qRT-PCR methodology, Vitalité produced the following results:
| Gene | Function | Vitalité Result | Direction |
|---|---|---|---|
| bdnf | Brain health · Neuroplasticity · Memory | +840% | Activate = good ✓ |
| glp-1 | Blood sugar regulation · Metabolic health | +348% | Activate = good ✓ |
| nrf1 | Energy levels · Cellular health | +224% | Activate = good ✓ |
| ppara | ATP energy production | +216% | Activate = good ✓ |
| nfkb | Inflammatory status | −172% | Suppress = good ✓ |
| il-6 | Inflammation marker | −112% | Suppress = good ✓ |
The 840% BDNF upregulation was the highest single gene expression result across all products tested in the study. BDNF — Brain-Derived Neurotrophic Factor — is the primary driver of neuroplasticity, memory consolidation, and cognitive resilience. According to the CDC, approximately 1 in 9 adults over 45 report subjective cognitive decline. The BDNF finding is why Vitalité is my first recommendation for professionals concerned about cognitive performance.
Important: These are in-vitro (cell culture) results. They are directionally meaningful but do not guarantee identical outcomes in human subjects.
↗ Read the Full Epigenetic Study (PDF)I am a 68-year-old Maryland State Certified Residential Appraiser with 35 years of professional practice. I do not attach my name to claims I cannot substantiate.
I took Vitalité daily for 3 years as part of my full THREE protocol. What I can report: energy consistency across the day became more predictable. The cognitive variability that I had accepted as normal in my mid-60s — good days and foggy days with no pattern — became less pronounced over the first 6 to 8 weeks. Morning readiness for demanding analytical work was more reliable.
I cannot tell you with certainty that any specific outcome was caused by Vitalité. What I can tell you is that the absorption data is real, the gene expression data is real, and my experience is consistent with what both would predict. That is the honest version of a personal assessment — which is the only kind I give.
Purchase THREE Vitalité through my ambassador account:
Purchase Vitalité → threeinternational.comInterested in the THREE International brand ambassador opportunity?
Explore the Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. This page contains affiliate links through which Ed may receive a commission on qualifying purchases. All scientific claims are independently cited. These statements have not been evaluated by the Food and Drug Administration. THREE International products are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Always consult your physician before starting a new supplement protocol.