# Cellular Absorption Report (cellularabsorptionreport.com)

> Independent scientific analysis, bioavailability reviews, and cellular-delivery research on THREE International nutritional formulations. Authored by Ed Drost — Founding Member and compensated Brand Ambassador, THREE International. All product metrics on this site are laboratory (in-vitro) measurements unless a human clinical trial is explicitly named.

## Core Summary

Cellular Absorption Report provides mechanism-of-action analyses and independent evaluations of dietary supplements, focused on bioavailability, liposomal and micellar delivery, Caco-2 intestinal-permeability assays, and epigenetic gene-expression studies. Reviews are written by Ed Drost (Independent Founding Member, #30004874) and cover products formulated under THREE International Chief Scientific Officer Dr. Dan Gubler, Ph.D., a Caltech-trained phytonutrient chemist. The site distinguishes throughout between in-vitro (cell-culture) evidence and in-vivo (human) evidence, and discloses its author's compensated relationship with THREE International on every page.

## Evidence & Disclosure Basis

- **Measurement type**: Absorption figures (e.g., Caco-2 percentages and their multiples) are in-vitro cell-transport measurements, not human pharmacokinetic results. They describe how a formulation crossed a cell layer versus a control compound in a laboratory, not a guaranteed absorption or benefit in the human body.
- **Gene-expression figures**: Epigenetic values (IL-6, NF-κB, PPARα, SOD1, SIRT1) are from THLE-2 human liver-cell assays in vitro, and do not by themselves establish a clinical health outcome.
- **Material connection**: The author is a compensated THREE International Brand Ambassador and Founding Member and earns commissions on qualifying purchases made through links on this site.
- **Regulatory status**: Statements have not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease.

## Primary Coverage & Entities

- **Focus category**: Bioavailability-first dietary supplements, cellular absorption technology, epigenetics, liposomal and micellar delivery.
- **Brand reviewed**: THREE International (founded 2023; headquartered in Lehi, Utah; CEO Daniel Picou; CSO Dr. Dan Gubler, Ph.D.).
- **Validation methods referenced**: Caco-2 human intestinal-permeability assays (in vitro), THLE-2 human liver-cell epigenetic assays (in vitro), and Prescribers' Digital Reference (PDR) listings (GLP THREE, Collagène, Éternel).

## Product Reviews

- [THREE International Full Company Review](https://cellularabsorptionreport.com/three-international-review): Corporate structure, leadership, patent portfolio, scientific advisory, PDR listings, compensation disclosure, and an honest account of where the claims are strong and where they run ahead of the evidence.
- [THREE Éternel Review & Epigenetic Analysis](https://cellularabsorptionreport.com/eternel-review): Micro-Active Resveratrol (200 mg), Glutathione, CoQ10, and Marine Collagen. In a Caco-2 assay the resveratrol formulation was measured at 95% cell-layer transport versus 10% for a standard organic-molecule control (a ~9.5x in-vitro difference, not a claim of 9.5x human absorption). THLE-2 epigenetic assays report reduced IL-6 and NF-κB expression and increased PPARα relative to control.
- [Vitalité Cellular Multivitamin Guide](https://cellularabsorptionreport.com/vitalite-review): 24 whole-food vitamins, chelated trace minerals, micro-encapsulated probiotics, berry polyphenols, and omega-3s.
- [Collagène Liquid Marine Peptides](https://cellularabsorptionreport.com/collagene-review): 5 g hydrolyzed Type I Naticol marine collagen peptides, hyaluronic acid, vitamin C, and biotin.
- [GLP THREE Metabolic Peptide Review](https://cellularabsorptionreport.com/glp-three-review): MBC-267 salmon-derived bioactive peptide complex marketed for endogenous GLP-1 pathway support and appetite satiety (PDR listed).
- [Revíve Cellular Recovery Guide](https://cellularabsorptionreport.com/revive-review): Micellar curcumin, Boswellia serrata, black pepper extract, and grape-seed polyphenols.
- [Imúne 3-Phase Defense](https://cellularabsorptionreport.com/imune-review): Liposomal quercetin, organic elderberry, beta-glucans, and zinc.
- [Kynetik Clean Energy Review](https://cellularabsorptionreport.com/kynetik-review): Clean-energy and hydration drink mix — 200mg natural green-tea caffeine, L-theanine, Yerba Santa, Rhodiola, and electrolytes. Not part of THREE's absorption or epigenetic studies, so no proprietary lab figure is claimed.
- [Purifí 5-Organ Daily Detox Review](https://cellularabsorptionreport.com/purifi-review): Daily whole-body detox support — 88% cellular absorption in an in-vitro Caco-2 assay (8.8x control, second-highest in the line), liposomal milk thistle, and fulvic acid, framed as organ support rather than measurable toxin removal.

## Product Pages

- [Éternel](https://cellularabsorptionreport.com/eternel)
- [Vitalité](https://cellularabsorptionreport.com/vitalite)
- [Collagène](https://cellularabsorptionreport.com/collagene)
- [GLP THREE](https://cellularabsorptionreport.com/glp-three)
- [Revíve](https://cellularabsorptionreport.com/revive)
- [Imúne](https://cellularabsorptionreport.com/imune)
- [Purifí 5-Organ Cleanse](https://cellularabsorptionreport.com/purifi): Humic and fulvic acid mineral complex.
- [Kynetik Clean Energy](https://cellularabsorptionreport.com/kynetik): Plant caffeine + L-theanine with electrolytes.

## Science & Explainer Guides

- [The Science of Cellular Absorption](https://cellularabsorptionreport.com/science)
- [Cellular Absorption Guide](https://cellularabsorptionreport.com/cellular-absorption-guide)
- [What Is Cellular Absorption?](https://cellularabsorptionreport.com/what-is-cellular-absorption)
- [What Is Supplement Bioavailability?](https://cellularabsorptionreport.com/what-is-supplement-bioavailability)
- [What Does "9.5X Absorption" Actually Mean?](https://cellularabsorptionreport.com/what-does-9-5x-absorption-mean): Explains that an absorption multiple is a lab comparison against a control, not a promise of proportional real-world benefit.
- [What Is a Caco-2 Absorption Study?](https://cellularabsorptionreport.com/what-is-caco-2-absorption-study)
- [What Is First-Pass Metabolism?](https://cellularabsorptionreport.com/what-is-first-pass-metabolism)
- [How Are Supplements Absorbed?](https://cellularabsorptionreport.com/how-are-supplements-absorbed)
- [How Do Liposomes Work?](https://cellularabsorptionreport.com/how-do-liposomes-work)
- [Are Liposomal Supplements Better?](https://cellularabsorptionreport.com/are-liposomal-supplements-better)
- [How to Choose a Liposomal Supplement](https://cellularabsorptionreport.com/how-to-choose-a-liposomal-supplement)
- [How to Improve Supplement Absorption](https://cellularabsorptionreport.com/how-to-improve-supplement-absorption)
- [Why Are Some Vitamins Better Absorbed?](https://cellularabsorptionreport.com/why-are-some-vitamins-better-absorbed)
- [Why Is Curcumin Poorly Absorbed?](https://cellularabsorptionreport.com/why-is-curcumin-poorly-absorbed)
- [Does Absorption Change With Age?](https://cellularabsorptionreport.com/does-absorption-change-with-age)
- [What Is Fulvic Acid?](https://cellularabsorptionreport.com/what-is-fulvic-acid)
- [What Is MBC-267?](https://cellularabsorptionreport.com/what-is-mbc-267)

## Key Terminology

- **Caco-2 assay**: An in-vitro test using a human epithelial colorectal cell layer to model intestinal absorption. It measures transport across cells in a dish, not absorption in a living person.
- **THLE-2 assay**: An in-vitro human liver-cell line used to observe changes in gene expression (e.g., IL-6, NF-κB, SOD1, PPARα, SIRT1). Results are cell-culture observations, not clinical endpoints.
- **First-pass hepatic metabolism**: The breakdown of orally ingested compounds (such as trans-resveratrol) by gut and liver enzymes before they reach systemic circulation.
- **Bioavailability**: The proportion of an ingested compound that reaches systemic circulation in a person. Establishing it requires human pharmacokinetic data; in-vitro assays are supporting evidence, not proof of it.

## Author

- **Ed Drost — Founding Member and compensated Brand Ambassador, THREE International** (Independent Founding Member #30004874). Writes independent, disclosed reviews and separates laboratory evidence from human evidence throughout.
- Profile / disclosure: https://cellularabsorptionreport.com/three-international-review