30% cellular absorption — 3× more than standard curcumin. The broadest epigenetic performer in THREE's study. SIRT1 longevity gene +164%. The data behind a recovery product that goes far beyond joints.
THREE Revíve is a renewal and recovery supplement (2 softgels daily or as needed, 60 softgels per jar) produced by THREE International. It uses quillaja saponins — plant molecules that self-assemble into micelles in solution — as the primary cellular delivery vehicle for its anti-inflammatory compounds.
Adjuvants piperine (black pepper extract) and menthol (peppermint oil) further increase cellular absorption of every ingredient in the formula. In THREE's Caco-2 assay, Revíve achieved 30% cellular absorption — 3× more bioavailable than the curcumin control at 10%.
Standard curcumin supplements — the most common natural joint support ingredient — have a documented bioavailability problem. At approximately 10% cellular absorption, most of what you swallow is metabolized before reaching the joint tissue it is intended to support. This explains the widespread experience of curcumin supplements producing no measurable benefit.
Revíve's quillaja micelle delivery solves this by encapsulating curcumin and all other active ingredients in self-assembling micelles — natural delivery vehicles that survive digestion and facilitate cellular uptake. The 3× improvement over the unformulated curcumin control is validated in THREE's Caco-2 study.
| Ingredient | Mechanism |
|---|---|
| Curcumin | Supports the body's natural inflammatory response. Joint health, muscle soreness, recovery. Delivered via quillaja micelles for 3× standard absorption. |
| Boswellia | Complements curcumin for joint support and post-exercise recovery. AKBA (acetyl-keto-beta-boswellic acid) inhibits specific inflammatory enzyme pathways. |
| Black Cumin Oil | Additional support for the body's natural inflammatory response via thymoquinone activity. |
| Quillaja Saponins | Self-assemble into micelles — THREE's primary CAT delivery vehicle for Revíve. Enables 30% cellular absorption of all active ingredients. |
| Grape Seed Extract | Proanthocyanins: aerobic endurance support, joint health, immune function. |
| Shiitake Mushroom | Ergothioneine accelerates muscle recovery and supports immune health. Accumulates specifically in tissues subject to high oxidative stress. |
| Sea Buckthorn Oil | Anti-fatigue phytonutrients for sustained physical performance. |
| Piperine + Menthol | Adjuvants that increase cellular absorption of all Revíve ingredients above their baseline levels. |
| Gene | Function | Revíve Result | Direction |
|---|---|---|---|
| ppara | ATP energy production | +384% | Activate ✓ |
| bdnf | Brain health · Cognitive function | +430% | Activate ✓ |
| nrf1 | Energy · Cellular health | +229% | Activate ✓ |
| glp-1 | Blood sugar · Metabolic health | +293% | Activate ✓ |
| sirt1 | Longevity · Cellular stress response | +164% | Activate ✓ |
| nfkb | Inflammatory status | −200% | Suppress ✓ |
| il-6 | Inflammatory marker | −123% | Suppress ✓ |
The SIRT1 +164% result is the most unexpected and the most differentiating. SIRT1 (sirtuin-1) is one of the most studied longevity proteins in biology — involved in cellular stress response, DNA repair, and aging rate regulation. No other curcumin or joint supplement on the market has run this test, because none have applied epigenetic methodology to a recovery formula. These are in-vitro results.
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Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.