At 68, after 36 years as a professional appraiser — a career that demands precision and primary-source verification — I approach health claims the same way I approach a valuation dispute. I go to the data. Here is everything I found about THREE International's cellular delivery technology, their clinical studies, and all 8 products in their line.
I'm Ed Drost — Maryland State Certified Residential Appraiser (#30004874), AI authority coach, THREE International Founding Member & Brand Ambassador in Parkton, MD. Not a doctor or nutritionist. A professional who spent 2 months vetting the science, flew to the launch convention, met the founders in person, and discloses his compensation. Every claim on this page is linked to its source.
36 years professional appraisal. AI coaching for professionals 45+. I spent 2 months independently reviewing THREE's clinical research, then attended the company's launch convention in Salt Lake City as a founding member — meeting co-founders Daniel Picou, Dr. Dan Gubler, Kim Hui, and Christene Peterson in person before THREE had shipped products at scale. The absorption science is real — here's exactly what the studies show.
THREE commissioned two independent studies — a Caco-2 cellular absorption assay and an epigenetic gene expression study — that are publicly available and linked below. Here is what they actually found.
How to read these numbers: the first two come from a laboratory cell-absorption assay; the last two from an in-vitro gene-expression study in liver cells. They are directional formulation evidence — meaningful, but not the same as human clinical outcomes, and they do not guarantee an identical result in your body. Each figure links to the full study below so you can verify it yourself. What these study types can and can't tell you →
Conducted by Dr. Brett Stephens, Ph.D. (Wasatch Scientific) and Dr. Dan Gubler, Ph.D. (THREE). The Caco-2 assay uses human intestinal epithelial cells to measure what percentage of a substance actually crosses the cellular membrane. Control: curcumin at 10% — a standard organic molecule with no delivery technology.
Compare each product to the curcumin control — not between products. Revíve at 30% is still 3× more bioavailable than the standard organic molecule baseline.
↗ Read the Full Absorption Study (PDF)Conducted by Paul Davis, Ph.D. & Catherine Davis, Ph.D. (Trinity Bioactives Ltd) with Dr. Dan Gubler. Used THLE-2 human liver cells and qRT-PCR gene expression analysis to measure whether THREE products modulate health-relevant genes. Four products tested: Vitalité, Revíve, Éternel, Collagène.
These are in-vitro (cell-culture) gene-expression results, reported by the study as fold-changes — a figure like "−1,250%" means a roughly 13-fold reduction in that gene's expression in the assay, not a reduction of more than 100%. They are directionally meaningful and mechanistically consistent with published research, but they do not guarantee identical outcomes in human subjects.
↗ Read the Full Epigenetic Study (PDF)Each product includes actual ingredients from THREE's official fact sheets, clinical study data where available, and my personal take after 6+ months of use. Purchase links go through my ambassador account.
BDNF supports neuroplasticity, memory, and cognitive resilience. Polyphenol-rich formulations have shown BDNF upregulation in multiple in-vitro and animal studies.
"Vitalité is where I tell anyone new to THREE to start. The BDNF number genuinely surprised me — cognitive performance is non-negotiable at 68, and this is the only supplement I've found with in-vitro data directly on that gene."
Salmon protein hydrolysate peptides demonstrated a 42% increase in glucose uptake in muscle cells and decreased hepatic glucose production in peer-reviewed studies.
GLP-1 receptor agonists have peer-reviewed evidence for reducing BMI, blood glucose, HbA1c, and sleep apnea severity in meta-analyses.
Saffron's crocetin was identified as a GPR40/GPR120 dual agonist — supporting insulin and GLP-1 secretion — for the first time in 2023.
"Of all THREE's products, GLP THREE has the deepest independent ingredient-science bibliography. The salmon-peptide research is real and the GLP-1 pathway is one of the most studied areas in metabolic science. What I'm careful to say: that's evidence about the pathway and the ingredients, not proof that this supplement replicates a prescription drug's results. If weight or metabolic health is your focus, this is worth researching — and worth discussing with your doctor first."
Rhodiola rosavins have demonstrated reduced mental fatigue, improved stress resilience, and enhanced cognitive performance in clinical trials.
L-theanine + caffeine combination consistently improves sustained attention and alertness while reducing anxiety — a well-replicated cognitive performance synergy.
"I'm 68 and spend long days between appraisal and content production. Kynetik gives clean, sustained energy without the rebound — the L-theanine + Yerba Santa combination is noticeably different from coffee. I don't drink it past 2pm."
Standard curcumin absorption is ~10% — validating that quillaja micelle delivery is necessary, not optional. Revíve at 30% is 3× more bioavailable than unformulated curcumin.
"I take Revíve on appraisal site visits, yard work, and workout days. What surprised me in the epigenetic data: Revíve led on the sirt1 longevity gene — for a joint recovery product, that's a significant bonus."
Silymarin (milk thistle) has demonstrated hepatoprotective effects in multiple controlled trials, including liver enzyme normalization and protection against oxidative damage to liver cells.
Fulvic acid has demonstrated ability to complex with heavy metal ions in laboratory settings, supporting its use as a detoxification cofactor.
"One capsule daily as a consistent practice — not a 3-day dramatic cleanse. The milk thistle and fulvic acid science is solid. I pair it with Vitalité every morning."
Hydrolyzed collagen peptides (GPRGPA, GPOGPA) have been detected accumulating in skin tissue after oral ingestion. RCTs show measurable improvements in skin elasticity and hydration.
Oral hyaluronic acid has been shown to reach joint synovial tissue and reduce knee discomfort in human clinical trials.
"The hydrolyzed vs. intact collagen absorption difference is real and published. The 10-day monthly cycle mirrors clinical trial design. My skin and joints both showed measurable improvement by month 3."
Quercetin shows antiviral, antibacterial, and immune-modulating effects across multiple studies. Liposomal delivery significantly improves quercetin bioavailability vs standard supplementation.
Medicinal mushrooms (reishi, maitake, Cordyceps, lion's mane) have extensive beta-glucan and immune modulation research, addressing both innate and adaptive immunity.
"The quorum sensing approach — targeting how bad bacteria communicate rather than overwhelming them with vitamin C — is genuinely novel. Zero sick days in 9 months. Correlation, not causation. But I'll take it."
Not a medical diagnostic. Select your primary wellness priority and I'll point you to the product and data most relevant to your situation.
What is your primary wellness focus right now?
This is a product orientation tool, not medical advice. Consult your physician before beginning any supplement protocol, especially if you take medications or have existing health conditions.
Questions I hear most often from professionals researching THREE International, bioavailability science, and whether these products might fit their wellness protocol.
That's the right question. My background is real estate valuation — 36 years appraising Baltimore-area properties, working estate and divorce cases, SDAT tax appeals, and multifamily assignments. I am not a nutritionist, biochemist, or physician.
What I am is a professional who has spent three decades being paid to assess the difference between a legitimate claim and an inflated one. When someone brought THREE International's science to my attention, I did what I always do: I pulled the studies, read the methodology, and looked at the data before forming an opinion. I spent two months doing exactly that before I made any decision.
Then I flew to Salt Lake City and attended THREE's launch convention as a founding member. I met Daniel Picou, Dr. Dan Gubler, Kim Hui, and Christene Peterson in person — the founders and leaders who built this company — before THREE had shipped products at scale. That meeting confirmed what the research had already told me: this company was built on a real foundation.
The Caco-2 absorption study is methodologically sound. The Caco-2 assay is a well-established pharmaceutical testing method — the same approach used to evaluate drug bioavailability. The epigenetic study used real human liver cell lines with published qRT-PCR methodology. These are not marketing documents — they are actual studies with actual methods sections.
Three years later, I'm still here. The science hasn't changed. The leadership hasn't changed. I also run a coaching practice at EdDrost.com helping professionals 45+ build AI-powered authority businesses. The philosophy is the same everywhere I work: do the homework, build on real foundations, be transparent about what you know and what you don't.
I disclose my compensation on every page. I link to every study I cite so you can read it yourself. That's the standard I hold myself to.