MBC-267™ — 267 salmon peptides binding the GLP-1 receptor. PDR-listed. Patent-pending. The peer-reviewed science behind the most clinically grounded natural weight management product available.
THREE GLP THREE is a natural weight management liquid dietary supplement produced by THREE International. It is built around MBC-267™ (Metabolic Boost Complex-267™) — a proprietary complex of 267 naturally-occurring peptides from Norwegian salmon protein hydrolysate and mushrooms, formulated to bind to the GLP-1 receptor.
MBC-267™ is patent-pending, exclusive to THREE International, and — significantly — is listed in the Prescribers' Digital Reference (PDR), the clinical resource used by physicians and pharmacists. This is an unusual distinction for a nutritional supplement and signals a level of clinical rigor that most products in this category cannot approach.
Protocol: ¾ dropper (0.83ml) approximately 30 minutes before meals. Approximately 12 servings per bottle.
GLP-1 (glucagon-like peptide-1) is a hormone produced in the gut in response to food intake. It signals the pancreas to release insulin, slows gastric emptying (keeping you full longer), and tells the brain's satiety centers to reduce appetite. GLP-1 signaling declines with age, contributing to increased food cravings, reduced satiety, and progressive weight gain even without significant dietary changes.
The GLP-1 pathway is currently the most intensively researched area in metabolic medicine. Pharmaceutical GLP-1 receptor agonists (Ozempic, Wegovy) have compelling clinical evidence but require injections, cost $900+ monthly, and carry documented side effects. GLP THREE supports the same pathway through natural peptides and botanicals with individual peer-reviewed mechanism studies.
Norwegian salmon protein hydrolysate peptides have demonstrated glucoregulatory and anti-inflammatory activity in multiple peer-reviewed studies:
Salmon protein hydrolysate peptides demonstrated a 42% increase in glucose uptake in muscle cells and ability to decrease hepatic glucose production.
GLP-1 receptor agonists have peer-reviewed evidence for reducing BMI, blood glucose, HbA1c, and sleep apnea severity in meta-analyses of clinical trials.
GLP-1 is secreted by L-cells — specialized enteroendocrine cells located predominantly in the distal small intestine and colon. When nutrients interact with L-cells, they trigger GLP-1 release into the bloodstream. MBC-267™'s 267 salmon peptides are specifically formulated to survive GI transit and interact with L-cell receptor pathways, stimulating endogenous GLP-1 secretion rather than introducing a synthetic hormone agonist from outside the body.
This is the fundamental mechanistic difference between GLP THREE and pharmaceutical GLP-1 agonists: GLP THREE supports the body's own L-cell production pathway; pharmaceutical agonists bypass it entirely with synthetic receptor binding. The supporting botanicals — ginsenosides (Panax ginseng), crocetin (saffron), and bitter acids (hops) — each independently stimulate L-cell GLP-1 secretion through different receptor pathways (GLP-1 receptor, GPR40/GPR120, TAS2R), creating a layered approach that no single-ingredient supplement can replicate.
| Ingredient | GLP-1 Mechanism & Peer-Reviewed Evidence |
|---|---|
| MBC-267™ (320mg) | 267 peptides from salmon protein hydrolysate + mushroom glycolipids. Binds GLP-1 receptor directly. Patent-pending. PDR-listed. Peer-reviewed glucoregulatory activity (Henaux 2019, Chevrier 2015). |
| Panax Ginseng Extract | Ginsenosides shown to stimulate GLP-1 secretion in experimental and human studies. Liu et al. (2013, Journal of Endocrinology); Wang et al. (2025, J Asian Natural Products Research). |
| Saffron Extract (Crocetin) | Crocetin identified as a dual GPR40/GPR120 agonist that enhances both insulin and GLP-1 secretion — first documented in 2023. Zhao et al. (2023, Nutrients). |
| Humulus Lupulus (Hops) | Hop bitter acids activate TAS2R bitter taste receptors in the gut to stimulate GLP-1 secretion. Barrea et al. (2019, Critical Reviews Food Sci Nutr); Lela et al. (2024, Mol Nutr Food Res). |
"GLP THREE has the deepest independent peer-reviewed bibliography of any THREE product. The salmon peptide research is real, the GLP-1 pathway has more clinical evidence behind it than almost any area in metabolic medicine, and the PDR listing adds a layer of professional credibility that most supplements in this category cannot approach." — Ed Drost, THREE Founding Member
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Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.