Ed Drost is a THREE International Founding Member & compensated Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease.
THREE International · Science, Leadership & Credentials

The Science Behind
THREE International

PDR recognition. A 9-member Scientific Advisory Board. Three independent clinical studies. The credentials behind the products — reviewed by THREE Founding Member Ed Drost.

PDR 63 · 2009
Physicians'
Desk
Reference
www.PDR.net
THREE Listed

THREE Is Recognized in the Prescribers' Digital Reference

The PDR is the most reputable and commonly used source of pharmaceutical, nutraceutical, and prescription drug information for medical professionals — physicians, pharmacists, and clinical practitioners.

THREE International's product line is recognized in the PDR and is accredited at the highest level of excellence across five criteria:

Proprietary Cellular Absorption Technology
Manufactured in the USA — cGMP, ASI, FDA Compliant
Quality Analysis, Quality Controlled & Third Party Tested
Formulated by THREE — Not White Labeled
Independent Clinical Studies

✓ Verified PDR Listings — Live Links

↗ Vitalité on PDR.net ↗ Vitalité Full PDR Listing ↗ THREE PDR Announcement

PDR.net requires free registration for full access. These links confirm THREE International's listing in the Prescribers' Digital Reference.

Company Leadership

The People Setting the Vision

Trusted. Proven. Purpose-Driven. THREE International was built by proven business leadership combined with elite scientific credentials — a combination that is rare in the supplement industry.

DP
Daniel Picou
Founder & CEO
  • 20+ years as innovative business leader
  • 8+ years in global e-commerce space
  • Built 2 successful digital services companies
  • Founded THREE International on purpose, impact, and collective good

"My goal is to change lives — for the better. Through better health and life-changing opportunity, we're creating a community built on purpose, impact, and collective good."

— Daniel Picou, Founder & CEO
DG
Dr. Dan Gubler, Ph.D.
Chief Scientific Officer
  • 18+ years of Cellular Absorption Formulation Experience
  • Formulated over 70+ nutritional supplements
  • 16 patents granted or pending
  • Caltech-trained — Ph.D. in Organic Chemistry
  • Health Influencer · Top 50 Podcast · 1M+ followers

"After 2 decades in the nutraceutical industry, I can confidently say THREE products are the best I've ever seen in the marketplace. No one matches THREE when it comes to quality, cellular absorption technology and credibility."

— Dr. Dan Gubler, CSO

Independent Clinical Research

Three Studies. All Publicly Available.

THREE International has commissioned three independent clinical studies using peer-reviewed methodology. Every study is publicly available — linked below and analyzed in full at this site.

01
Cellular Absorption Study (Caco-2)
Conducted by Dr. Brett Stephens, Ph.D. (Wasatch Scientific) and Dr. Dan Gubler, Ph.D. using the Caco-2 permeability assay — the same methodology pharmaceutical companies use to test drug bioavailability. Tested all core THREE products against a curcumin control at 10% absorption.
Results: THREE products are up to 9.5× more absorbable than the standard organic molecule control
↗ Read Full Study (PDF)
02
Epigenetics Clinical Study
Conducted by Paul Davis, Ph.D. & Catherine Davis, Ph.D. (Trinity Bioactives Ltd) with Dr. Dan Gubler using THLE-2 human liver cells and qRT-PCR gene expression methodology. Tested Éternel, Vitalité, Revíve, and Collagène against 8 health-relevant genes.
Results: THREE products have a positive impact on regulating or suppressing certain gene functions — including IL-6 −1,250% and BDNF +840%
↗ Read Full Study (PDF)
03
Superoxide Production Study
An independent product study measuring Revíve's effect on superoxide production — a key marker of oxidative stress and muscle damage following exercise. Superoxide is the primary free radical produced during physical exertion that impairs muscle recovery.
Results: Revíve supports muscle recovery by inhibiting superoxide production by up to 36%
↗ Read Full Study (PDF)

Manufacturing Standards

THREE International manufactures all products in-house in the USA — not white-labeled from third-party manufacturers. Every product is subject to:

cGMP Certified Manufacturing
ASI Compliant
FDA Compliant Facility
Quality Analysis
Quality Controlled
Third Party Tested
Not White Labeled
PDR Recognized
Scientific Advisory Board

9 Credentialed Physicians and Scientists

THREE International's Scientific Advisory Board provides independent medical oversight of formulations, clinical research, and product development. Nine board members spanning internal medicine, oncology, sports medicine, nutrition science, and pharmaceutical research.

CG
Dr. Charles Greene
MD, Ph.D.
Scientific Advisory Board Member
DL
Dr. Deirdre Leak
MD
Scientific Advisory Board Member
JB
Dr. James Baker
DO, FACOI
Scientific Advisory Board Member
LG
Dr. Lana Galicia
MD
Scientific Advisory Board Member
SS
Dr. Stephen Sabo
MD
Scientific Advisory Board Member
JB
Dr. Jessica Bordon
DPM, PA
Scientific Advisory Board Member
NY
Dr. Naoko Yoshimura
MD
Scientific Advisory Board Member
SP
Prof. Sastia Putri
Ph.D.
Scientific Advisory Board Member
RR
Dr. Roy Rong
MD
Scientific Advisory Board Member

Why This Matters — Ed Drost's Perspective

Why a 68-Year-Old Appraiser Trusts These Credentials

In 35 years of professional appraisal work, I've been paid to assess the difference between a legitimate claim and an inflated one. When someone brought THREE International to my attention, I evaluated it the same way I evaluate every property: I looked at what was actually there.

The PDR listing is real and verifiable. The Caco-2 study methodology is the same one pharmaceutical companies use. The epigenetic study used human liver cell lines with published qRT-PCR methodology. The Scientific Advisory Board includes nine credentialed physicians. Dr. Gubler's 16 patents are a matter of record.

I spent 2 months independently reviewing all of this before I flew to Salt Lake City for THREE's launch convention as a Founding Member. I met Daniel Picou and Dr. Dan Gubler in person. The science held up. The leadership held up. Three years later, I'm still here.

Everything I reference on this site is linked to its primary source. If you want to verify any of it — and I encourage you to — the study PDFs are on THREE's media server and linked throughout this site.

Shop All THREE Products → Explore Ambassador Opportunity →
Frequently Asked Questions

Common Questions About THREE International's Credentials

Yes. THREE International's product line is recognized in the Prescribers' Digital Reference (PDR) — the most reputable and commonly used source of pharmaceutical and nutraceutical information for medical professionals. THREE is accredited at the highest level of excellence, recognized for its Proprietary Cellular Absorption Technology, USA manufacturing (cGMP, ASI, FDA compliant), Quality Analysis and Third Party Testing, proprietary formulation (not white-labeled), and independent clinical studies. This is an unusual distinction for a nutritional supplement company.
Dr. Dan Gubler, Ph.D. is THREE International's Chief Scientific Officer. He holds a doctorate in Organic Chemistry from Caltech, has 18+ years of cellular absorption formulation experience, has formulated over 70 nutritional supplements, holds 16 patents granted or pending, and has a health/wellness following of over 1 million with a top-50 podcast. He co-authored THREE's Caco-2 absorption study and the 2023 epigenetic gene expression study. He states: "After 2 decades in the nutraceutical industry, I can confidently say THREE products are the best I've ever seen in the marketplace."
Yes. THREE International has a 9-member Scientific Advisory Board: Dr. Charles Greene (MD, Ph.D.), Dr. Deirdre Leak (MD), Dr. James Baker (DO, FACOI), Dr. Lana Galicia (MD), Dr. Stephen Sabo (MD), Dr. Jessica Bordon (DPM, PA), Dr. Naoko Yoshimura (MD), Professor Sastia Putri (Ph.D.), and Dr. Roy Rong (MD). This board provides independent medical and scientific oversight of THREE International's formulations and research.
THREE International has published three independent clinical studies: (1) Caco-2 Cellular Absorption Study — products are up to 9.5× more bioavailable than the standard organic molecule control; (2) Epigenetics Clinical Study — showing significant gene expression modulation including IL-6 suppression −1,250% for Éternel and BDNF upregulation +840% for Vitalité; (3) Superoxide Production Study — Revíve inhibits superoxide production by up to 36%, supporting muscle recovery. All three studies are publicly available and linked at CellularAbsorptionReport.com/science.
THREE International products are manufactured in the USA in cGMP, ASI, and FDA-compliant facilities. Products undergo Quality Analysis, Quality Control, and Third Party Testing. THREE formulates all products in-house — they are not white-labeled from other manufacturers. This is a significant differentiator in a supplement industry where white-labeling is the norm.

Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. This page contains affiliate links. All scientific claims are independently cited from primary sources. Not evaluated by the FDA. THREE International products are not intended to diagnose, treat, cure, or prevent any disease.