88% cellular absorption — 8.8× vs standard control. Liposomal silymarin, fulvic acid heavy metal binding, 5-organ daily support. The honest science behind why one capsule daily outperforms any 3-day cleanse.
THREE Purifí is a daily whole-body detox supplement (1 capsule daily, 30 capsules per bottle) produced by THREE International. It supports 5 elimination organs simultaneously — liver, colon, kidneys, lungs, and skin — in a single daily capsule.
An important framing note: your liver and kidneys are your actual detoxification system. No supplement replaces them. What Purifí provides are evidence-backed cofactors that support those organs' natural processes — a meaningfully different and scientifically defensible claim from the dramatic cleanse marketing that dominates this category.
| Ingredient | Organ Target & Evidence |
|---|---|
| Fulvic Acid (Humic Shale) | All organs / Heavy metals: Forms complexes with heavy metal ions (Hg, Pb, Cd) for elimination. Increases cellular absorption. Supports mitochondrial function. (Rashid et al. 2016, Int J Mol Sci) |
| Liposomal Milk Thistle | Liver: Silymarin — most studied hepatoprotective botanical. Demonstrated hepatoprotective effects in controlled trials including liver enzyme normalization (Abenavoli et al. 2010; Federico et al. 2017). Liposomal delivery improves bioavailability vs standard milk thistle. |
| Chlorophyllin Capsule | GI tract / Toxin binding: Water-soluble chlorophyll derivative. Efficiently binds to toxins and carcinogens in the gut before they can be reabsorbed, facilitating elimination. |
| Kelp + Apple Pectin | Colon: Support colon health and gut microbiome. Feed beneficial bacteria. Apple pectin forms a gel that binds toxins in the colon for elimination. |
| Coriander + Dandelion Root | Kidneys/Gallbladder: Apigenin and arctiin support kidney and gallbladder function. Dandelion is one of the most studied botanicals for kidney and liver support. |
| Mullein Leaf | Lungs: Saponins and iridoid glycosides maintain lung and respiratory health. Traditional use backed by multiple botanical medicine reviews. |
| Stinging Nettle | Urinary/Skin: Flavonoids maintain urinary system health and support skin elimination function. |
| Burdock Root | Liver: Arctiin supports liver detoxification function alongside silymarin. |
Silymarin (milk thistle extract) has demonstrated hepatoprotective effects in multiple controlled trials, including liver enzyme normalization and protection against oxidative damage to liver cells.
Fulvic acid has demonstrated ability to complex with heavy metal ions in laboratory settings, consistent with traditional use as a detoxification support compound.
"One capsule daily as a consistent practice — not a 3-day dramatic cleanse. The liver doesn't take weekends off. Your detox support shouldn't either." — Ed Drost, THREE Founding Member
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Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.