Quorum sensing inhibition. Adaptive immunity. Innate immunity. 80% of your immune system is gut-resident. Here's the three-system architecture designed around where immunity actually lives — with full citations.
THREE Imúne is a total body immune support supplement (2 capsules daily, 60 capsules per jar, fully vegan) produced by THREE International. Rather than loading vitamins C and D in large doses, it uses a three-system approach that addresses immune mechanisms standard supplements entirely ignore.
Quorum sensing is how pathogenic bacteria coordinate. When they accumulate in sufficient density, they use chemical signaling to organize — forming biofilms, increasing virulence, and mounting coordinated resistance. Standard supplements address none of this. Imúne's quorum sensing inhibition blend disrupts bacterial communication before it escalates.
| Ingredient | Role |
|---|---|
| Liposomal Quercetin | Documented quorum sensing inhibition activity. Antiviral and antibacterial effects. Liposomal delivery for 4.4× improved bioavailability vs standard quercetin. (Boots et al. 2008; Riva et al. 2019) |
| Reishi Mushroom | Beta-glucan immune modulation. Quorum sensing inhibition via polysaccharide activity. |
| Agaricus Blazei | Specific immune-activating beta-glucans. Enhanced natural killer cell activity. |
| Nano Silver | Broad-spectrum antimicrobial. Disrupts bacterial cell membrane integrity. |
| Zinc + Vitamin C | Standard immune support cofactors within the quorum sensing blend context. |
| Ingredient | Role |
|---|---|
| Cordyceps sinensis | Adaptogenic mushroom with documented NK cell and T-cell activity. Enhances adaptive immune response speed and specificity. |
| Maitake Mushroom | D-fraction beta-glucans with extensive immune modulation research. Activates macrophages and dendritic cells. |
| Aquamin TG | Multi-mineral complex supporting cellular immune function. |
| Vitamin A + Selenium | Essential cofactors for adaptive immune cell development and function. |
| Ingredient | Role |
|---|---|
| Elderberry | Well-documented innate immune support. Flavonoid content with antiviral activity. |
| Lion's Mane Mushroom | Hericenones and erinacines support nerve growth factor and gut-immune connection. Active in gut-associated immune tissue. |
| Vitamin D3 | Critical immunomodulator. Deficiency linked to impaired innate immune response across population studies. |
| Aloe Vera | Supports gut lining integrity — directly relevant to the gut-immune connection. 80% of immune cells are gut-resident. |
| Vitamin E + Calcium | Antioxidant protection of immune cells. Cellular signaling support. |
Medicinal mushrooms (reishi, maitake, Cordyceps, lion's mane) have extensive research on beta-glucan content and immune modulation, addressing different aspects of both innate and adaptive immunity.
Quercetin demonstrates antiviral, antibacterial, and immune-modulating effects across multiple peer-reviewed studies. Liposomal delivery significantly improves quercetin bioavailability vs standard supplementation.
"The quorum sensing approach — targeting how bad bacteria communicate rather than just overwhelming them with vitamin C — is the most novel immune mechanism I've found in any supplement. Nine months of daily use. Zero sick days. Correlation, not causation. But I'll take it." — Ed Drost, THREE Founding Member, age 68
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Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.