73% cellular absorption. 7.3× more bioavailable than standard collagen. BDNF +570% in the epigenetic study. The molecular size science that separates hydrolyzed marine peptides from every collagen powder you've tried before.
THREE International Collagène is a premium liquid dietary supplement designed to promote vibrant skin, hair, nails, and joint health. It is widely recognized for its high bioavailability, using Cellular Absorption Technology that is clinically shown to be 7.3× more absorbable than standard organic molecules.
It contains 5 grams of hydrolyzed and micronized marine collagen peptides from wild-caught sustainable fish, pomegranate juice concentrate (punicalagins), hyaluronic acid, hydrolyzed keratin, biotin (Vitamin B7), and Vitamin C. Contains no artificial ingredients, gluten, wheat, dairy, soy, or added sugars.
Protocol: 1 packet per day for 10 consecutive days, repeated monthly.
The collagen supplement market has produced one of the most widespread wellness disappointments. People add collagen powder to their coffee for months, see little to no change, and conclude that collagen doesn't work. Almost always the problem is the molecular size of the delivery — not the concept.
Intact collagen molecules are among the largest proteins in biology. When swallowed as powder, they cannot cross the intestinal lining intact. They break down into generic amino acids during digestion, losing the specific peptide sequences that accumulate in skin and joint tissue and trigger collagen synthesis.
Specific collagen peptides (GPRGPA and GPOGPA) have been detected in human blood following oral hydrolyzed collagen ingestion and shown to accumulate in dermal skin tissue. Randomized controlled trials demonstrate measurable improvements in skin elasticity and hydration.
Oral hyaluronic acid has been shown to reach joint synovial tissue and reduce knee joint discomfort in human clinical trials, challenging earlier assumptions about pre-absorption degradation.
THREE Collagène uses hydrolysis (enzymatic breakdown into di- and tri-peptide chains) plus micronization (further particle-size reduction) to create collagen fragments small enough to cross the intestinal membrane efficiently. The validated result: 73% cellular absorption in THREE's Caco-2 assay versus 10% for the standard control.
"Collagen works. Standard collagen powder delivery doesn't. The hydrolyzed and micronized distinction is the difference between a supplement that shows up in your skin tissue and one that shows up in your urine." — Ed Drost, THREE Founding Member
| Ingredient | What It Does |
|---|---|
| Marine Collagen (5g) | 5 grams of premium-sourced liquid peptides that easily enter the bloodstream. Hydrolyzed AND micronized. Wild-caught sustainable fish. Specifically processed into di- and tri-peptide chains (GPRGPA, GPOGPA) that have been detected accumulating in skin tissue in peer-reviewed research. |
| Pomegranate Juice Concentrate | Rich in punicalagins that stimulate cellular collagen production — re-training cells to turn the body's own natural collagen synthesis back on at the genetic level. Also provides antioxidant polyphenols that drive the BDNF epigenetic result. |
| Hyaluronic Acid | Maximizes skin suppleness by locking in moisture and preventing water loss. Supports elastin production. Oral HA has been shown to reach joint synovial tissue and reduce knee discomfort in human clinical trials. |
| Keratin (Hydrolyzed) | Hydrolyzed form for superior bioavailability vs standard keratin. Essential nutrients that build structural strength in hair, skin, and nails. |
| Biotin (Vitamin B7) | Essential nutrient for hair, skin, and nail health. Supports keratin infrastructure and cellular metabolism. |
| Vitamin C | A potent antioxidant that prevents skin damage and aids collagen synthesis. The body cannot produce collagen without Vitamin C — it is a mandatory cofactor in the collagen synthesis pathway. |
THREE Collagène delivers 5 grams of highly bioavailable marine collagen to support a firm, glowing complexion. Natural collagen production declines approximately 1% per year after age 25 and accelerates significantly after 50. No topical cream can reverse this — collagen synthesis happens at the dermal layer, three layers below the surface where topicals cannot reach. Oral hydrolyzed collagen peptides accumulate in dermal tissue (Asserin et al., 2015; Proksch et al., 2014) — the only delivery route that actually works.
Pomegranate punicalagins re-train cells to turn the body's own natural collagen production back on. This is a gene-activation mechanism — not simply adding collagen from outside the body, but stimulating the body's own synthesis pathway. This distinction is why Collagène's 10-day protocol produces results that standard collagen powder cannot replicate even at higher doses.
Collagen is the most abundant structural protein in the human body — present in skin, joints, tendons, ligaments, cartilage, hair, nails, and gut lining simultaneously. Collagène's hydrolyzed keratin supports hair and nail strength. Hyaluronic acid supports joint lubrication. The full-body structural protein story goes far beyond skin.
Contains no artificial ingredients, gluten, wheat, dairy, soy, corn, nuts, oats, sugar, artificial preservatives, lubricants, or fillers.
| Gene | Function | Collagène Result | Direction |
|---|---|---|---|
| bdnf | Brain health · Neuroplasticity · Memory | +570% | Activate = good ✓ |
| ppara | ATP energy production | +117% | Activate = good ✓ |
| sod1 | Antioxidant status | +122% | Activate = good ✓ |
| nfkb | Inflammatory status | −125% | Suppress = good ✓ |
The BDNF +570% result was unexpected and is the most notable finding — attributed to the pomegranate punicalagin polyphenol content. Collagène is the only collagen supplement with in-vitro data showing BDNF (brain health) gene activity. These are in-vitro results and do not guarantee identical outcomes in human subjects.
↗ Read the Full Epigenetic Study (PDF)I am 68 years old. I began taking Collagène as part of my THREE Founding Member protocol. By month 3, I noticed measurable differences in skin quality and joint comfort on physical workdays. I cannot isolate how much is Collagène versus other protocol changes, but my experience over 3 years is consistent with what the absorption data and clinical research would predict.
Of all THREE products, Collagène has the most straightforward and well-replicated peer-reviewed evidence base behind its mechanism. The hydrolyzed peptide accumulation research (Asserin 2015, Proksch 2014) is RCT-level evidence. The hyaluronic acid joint research (Kalman 2008) is human clinical trial data. This is the product I can explain most confidently to a skeptic.
Purchase THREE Collagène (10 packets — one complete monthly cycle):
Purchase Collagène → threeinternational.comInterested in the THREE International ambassador opportunity?
Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. Affiliate links present. Not evaluated by the FDA. Not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.