Micro-Active Resveratrol, Glutathione, CoQ10, and the 1,250% IL-6 suppression result. A THREE Founding Member's honest review with full citations — the science THREE's own product page doesn't show you.
THREE Éternel is an antioxidant super-blend liquid dietary supplement produced by THREE International (iii International LLC, Lehi, Utah). It is designed as a daily liquid gel packet using the company's Micro-Active cellular absorption technology to maximize bioavailability of its active compounds and protect cells from premature aging.
The product comes as 30 liquid gel packets per box — one per day. It contains no artificial ingredients, colors, flavors, additives, gluten, casein, wheat, dairy, soy, corn, nuts, oats, lubricants, binders, fillers, or TiO2.
I became a THREE Founding Member after 2 months of independently reviewing the clinical research — including Éternel's absorption data and the epigenetic gene expression results. I have taken Éternel daily for 3 years. It is the product I recommend first to professionals over 55 who are concerned about cellular aging and inflammation.
Éternel's formula is built around five primary ingredient categories, each selected for a specific mechanism of action against oxidative stress and cellular aging:
| Ingredient | Mechanism & Evidence |
|---|---|
| Micro-Active Resveratrol (200mg) | Particle-size-reduced trans-resveratrol. Addresses the documented first-pass metabolism problem (Walle T., 2011, Annals NY Academy of Sciences). Supports heart health, antioxidant activity, longevity pathways, and SIRT1 activation (Timmers et al., 2011, Cell Metabolism). Achieves 95% cellular absorption vs. 10% for standard resveratrol forms. |
| Glutathione | Often called nature's "master antioxidant." The body's primary endogenous antioxidant — neutralizes free radicals, reduces oxidative stress, and plays a central role in cellular detoxification. Glutathione levels decline with age, accelerating oxidative cellular damage. |
| Coenzyme Q10 (CoQ10) | A critical coenzyme that assists in mitochondrial electron transport chain function, driving natural cellular energy production (ATP). CoQ10 levels decline measurably with age. Research by Mortensen et al. (2014, JACC Heart Failure) demonstrated improved mitochondrial function markers with CoQ10 supplementation in older adults. |
| Marine Collagen | Provides essential structural proteins to support skin elasticity and a glowing complexion. Also contributes to the product's antioxidant profile through collagen-associated polyphenols. |
| 10 Superfruits Blend | Açai, pomegranate, mangosteen, goji berry, and 6 additional superfruits. Packed with polyphenols and phytonutrients with protective antioxidant activity. The polyphenol density of this blend drives the anti-inflammatory gene expression results in the epigenetic study. |
Resveratrol is one of the most researched longevity compounds in nutritional science. Harvard's David Sinclair has spent decades documenting its effects on SIRT1 — the longevity-associated protein. The science is compelling. The delivery problem is equally well-documented.
Standard resveratrol undergoes extensive first-pass metabolism in the gut and liver before reaching systemic circulation. T. Walle's 2011 paper in the Annals of the New York Academy of Sciences documents this clearly. Most resveratrol you swallow in a standard capsule never reaches the cells it is intended to support.
Trans-resveratrol's bioavailability challenge via first-pass metabolism is extensively documented. Particle-size reduction and nanoformulation approaches significantly improve plasma levels vs. standard oral supplementation.
Resveratrol activates SIRT1, a key longevity-associated protein involved in cellular stress response, DNA repair, and aging rate regulation. Research spans cardiovascular, metabolic, and aging biology contexts.
THREE's Micro-Active technology uses particle-size reduction to engineer resveratrol molecules small enough to cross the intestinal membrane before the hepatic first-pass metabolism cycle eliminates them. The result — validated in the Caco-2 pharmaceutical absorption assay — is 95% cellular absorption.
THREE International's complete product line — including Éternel — is listed in the Prescribers' Digital Reference (PDR). The Vitalité listing is verified at pdr.net (druglabelid=24471). THREE PDR announcement →
"I spent three years taking premium resveratrol supplements that felt like nothing. After reading Walle's 2011 paper alongside THREE's Caco-2 data, the reason was obvious. The ingredient was right. The delivery was failing. Micro-Active technology solves the problem the science identified." — Ed Drost, THREE Founding Member
THREE International commissioned a Caco-2 permeability assay conducted by Dr. Brett Stephens, Ph.D. (Wasatch Scientific) and Dr. Dan Gubler, Ph.D. (THREE International). The Caco-2 assay uses human intestinal epithelial cells to measure apparent permeability coefficient — the percentage of a substance that actually crosses the cellular membrane. This is the same methodology pharmaceutical companies use to evaluate drug bioavailability in pre-clinical trials.
In THREE's 2023 epigenetic gene expression study, conducted by Paul Davis, Ph.D. and Catherine Davis, Ph.D. (Trinity Bioactives Ltd) with Dr. Dan Gubler, using THLE-2 human liver cells and qRT-PCR gene expression methodology, Éternel produced the following results. Every result moved in the desired direction for cellular health and longevity:
| Gene | Function | Éternel Result | Direction |
|---|---|---|---|
| il-6 | Primary inflammatory cytokine marker of cellular aging | −1,250% | Suppress = good ✓ Strongest result in entire study |
| nfkb | Inflammatory status — master regulator of inflammatory response | −345% | Suppress = good ✓ |
| ppara | ATP energy production — governs mitochondrial energy metabolism | +380% | Activate = good ✓ |
| sod1 | Antioxidant status — superoxide dismutase 1 | +123% | Activate = good ✓ |
The IL-6 suppression result of 1,250% was the single strongest gene expression result across all products and all genes tested in the entire study. IL-6 is a primary inflammatory cytokine — one of the key molecular markers of the chronic, low-grade inflammation that researchers increasingly associate with accelerated cellular aging, cardiovascular disease, and cognitive decline.
Important: These are in-vitro (cell culture) results using human liver cells. They are directionally meaningful but do not guarantee identical outcomes in live human subjects.
Based on the clinical data and ingredient mechanisms, THREE Éternel is designed to support four primary areas:
Glutathione, CoQ10, Micro-Active Resveratrol, and the 10-superfruit polyphenol blend work synergistically to neutralize free radicals and reduce oxidative stress at the cellular level. The combination of the body's primary endogenous antioxidant (glutathione) with a high-absorption exogenous antioxidant (resveratrol) represents a layered cellular defense approach.
Chronic low-grade inflammation — driven by IL-6 and nfkb activation — is increasingly recognized as the primary driver of accelerated cellular aging. Éternel's 1,250% IL-6 suppression and 345% nfkb suppression in the epigenetic study directly address this mechanism. The anti-aging claim is supported by gene expression data, not just ingredient theory.
CoQ10 supports mitochondrial electron transport chain function — the mechanism by which cells produce ATP energy. The 380% ppara gene upregulation in the epigenetic study supports ATP energy production at the gene expression level. Together these mechanisms address the cellular energy decline that manifests as inconsistent energy in adults over 50.
The 10-superfruit polyphenol blend provides plant-based phytonutrients that support the body's natural response to UV exposure and environmental oxidative stress. THREE's product documentation specifically notes UV shielding as a Éternel benefit.
I am a 68-year-old Maryland State Certified Residential Appraiser. I became a THREE Founding Member by attending the launch convention in Salt Lake City after 2 months of independent research. I do not attach my name to claims I cannot substantiate — I have spent 35 years in a licensed profession where overstating value has legal consequences.
I have taken Éternel daily for 3 years. What I can honestly report: energy consistency improved within the first 6 weeks — not dramatically, not in a single-day transformation, but in a reduction of variability. The floor of my daily function went up. The cognitive and physical variability that I had accepted as normal in my mid-60s became less pronounced and less frequent.
I cannot prove causation. I can tell you that the absorption data is real, the gene expression data is real, and my experience over 3 years is consistent with what both predict. That is the honest version of a personal assessment.
Purchase THREE Éternel through my ambassador account (30 liquid gel packets):
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Explore the THREE Ambassador Opportunity →Ambassador Disclosure: Ed Drost is a compensated THREE International Founding Member and Brand Ambassador. This page contains affiliate links. All scientific claims are independently cited. Not evaluated by the FDA. THREE International products are not intended to diagnose, treat, cure, or prevent any disease. Individual results vary. Consult your physician before starting any supplement protocol.